Answer:
Hepato- and nephrotoxicity of fluoride have been demonstrated in animals, but few studies have examined potential effects in humans. This population-based study examines the relationship between chronic low-level fluoride exposure and kidney and liver function among United States (U.S.) adolescents. This study aimed to evaluate whether greater fluoride exposure is associated with altered kidney and liver parameters among U.S. youth.
This cross-sectional study utilized data from the National Health and Nutrition Examination Survey (2013–2016). We analyzed data from 1983 and 1742 adolescents who had plasma and water fluoride measures respectively and did not have kidney disease. Fluoride was measured in plasma and household tap water. Kidney parameters included estimated glomerular filtration rate (calculated by the original Schwartz formula), serum uric acid, and the urinary albumin to creatinine ratio. Liver parameters were assessed in serum and included alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, blood urea nitrogen, gamma-glutamyl transferase, and albumin. Survey-weighted linear regression examined relationships between fluoride exposure and kidney and liver parameters after covariate adjustment. A Holm-Bonferroni correction accounted for multiple comparisons.
The average age of adolescents was 15.4 years. Median water and plasma fluoride concentrations were 0.48 mg/L and 0.33 μmol/L respectively. A 1 μmol/L increase in plasma fluoride was associated with a 10.36 mL/min/1.73 m2 lower estimated glomerular filtration rate (95% CI: −17.50, −3.22; p = 0.05), a 0.29 mg/dL higher serum uric acid concentration (95% CI: 0.09, 0.50; p = 0.05), and a 1.29 mg/dL lower blood urea nitrogen concentration (95%CI: −1.87, −0.70; p < 0.001). A 1 mg/L increase in water fluoride was associated with a 0.93 mg/dL lower blood urea nitrogen concentration (95% CI: −1.44, −0.42; p = 0.007).
Fluoride exposure may contribute to complex changes in kidney and liver related parameters among U.S. adolescents. As the study is cross-sectional, reverse causality cannot be ruled out; therefore, altered kidney and/or liver function may impact bodily fluoride absorption and metabolic processes.
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Answer:
Derived traits shared among the species or other groups in a dataset are key to helping us build trees. As shown above, shared derived traits tend to form nested patterns that provide information about when branching events occurred in the evolution of the species.
Explanation:
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Answer:
(i) An allele is a variant of a gene, can either be short or tall.
Dominant = the tall allele that "trumps" the short allele. if a dominant and recessive allele is present (heterozygous) then the dominant phenotype will be shown.
(ii) David's eyes are Brown
(iii) Sarah's eyes are blue
(iv) David - B, b
Sarah - b, b
(v) Possible genotypes include Bb and bb. These give the phenotypes of brown eyes or blue eyes.
(vi) The chance for blue eyes is 50% (or 1:1 ratio)
Answer:
causes a cell to change: hypotonic,hypertonic
doesnt change the shape of the cell: isotonic
I dont know what the 3rd one is
Causes a cell to shrink:Hypertonic
Explanation:
Responder: Un pronóstico de siete días puede predecir con precisión el clima alrededor del 80 por ciento del tiempo y un pronóstico de cinco días puede predecir con precisión el clima aproximadamente el 90 por ciento del tiempo. Dado que no podemos recopilar datos del futuro, los modelos tienen que usar estimaciones y suposiciones para predecir el clima futuro.
