The myosin head separates from actin as a result of ATP binding. The intrinsic ATPase activity of myosin then transforms ATP into ADP and Pi. The myosin head's angle is altered into a cocked state by the energy generated during ATP hydrolysis. The myosin head is now ready to move in the future.
The myosin protein is in a high-energy conformation when the head is cocked. At the end of the power stroke, the myosin head is in a low-energy position because this energy has been used up during the power stroke. ADP is released following the power stroke, but the cross-bridge is still there and actin and myosin are joined together.
Since ATP is readily available, the cross-bridge cycle can repeat, and muscular contraction can go on as long as ATP is there.
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One negative side effect of with anaerobic synthesis of energy is that a by product of glycolysis is lactic acid
lactic acid cause muscle fatigue and post exercise muscle soreness. when you exercise the body uses oxygen to break down glucose for energy. when one do intensive exercise, oxygen may not be enough therefore lactic acid is produced.
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