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LuckyWell [14K]
3 years ago
6

What happens during the first step in DNA replication?

Biology
2 answers:
Nina [5.8K]3 years ago
7 0

The first step in DNA replication is the separation of the two DNA strands that make up the helix that is to be copied.

WITCHER [35]3 years ago
3 0

It starts when a protein starts the unwinding of the DNA helix. Next comes the separation of the DNA strands right before the transfer of genetic data to the newly assembled DNA strands starts. A protein known as helicase is what breaks down the hydrogen bonds between strands of DNA during replication.

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A gene is involved in promoting limb development in humans. The gene is initially weakly activated during the limb induction pha
Anna [14]

Answer:

1. If the gene is weakly activated, it likely lacks repressive histone modifications, but may also lack the presence of histone marks associated with strong transcriptional activation such as acetylation.

When the gene is strongly activated, it likely lacks repressive marks (such as H3K9me2/3 and H3K27me3 - both examples of repressive histone methylation) and might possess some activating histone acetylation marks, such as H3K4ac, and active histone methylation such as H3K4me3

<em>An aside: The pattern and presence of different histone modifications would depend on the gene, but based on the fact that it is a developmental gene, I would assume that H3K27me3 and H3K4me3 are at play (these are part of the Polycomb/Trithorax system)</em>

<em />

After limb growth is complete, the gene is turned off. Repressive histone methylation marks would be associated with this state, such as the aforementioned H3K9me2/3 or H3K27me3.

2. Histone modifications are tightly linked to genome organisation. Histone methylation marks associated with repression such as H3K27me3 and H3K9me3 are associated with compact chromatin structures, which restrict the access of transcriptional machinery and other positive regulators. Conversely, histone marks associated with gene activation are associated with a more permissive chromatin environment that facilitates the binding of factors associated with gene expression. In the case of histone acetylation, the acetyl mark directly removes the positive charge of chromatin, relaxing its interaction with negatively charged DNA.

3. If the inappropriate activation of this gene caused a cancerous tumor, this gene would be referred to as an oncogene (or a proto-oncogene for the term before it is inappropriately activated).

Typically, there are two classes of genes that lead to cancer: tumor-suppressor genes and oncogenes. Tumor suppressor genes lead to cancer when their protective activity is reduced or demolished, leading to the production of cancer cells. Oncogenes lead to cancer when they become over active. Oncogenes are often genes associated positively with growth and proliferation, consistent with the gene in this example.

8 0
3 years ago
What to do to reduce weight and become thin in 1 month
Gennadij [26K]

Answer:

Eat fig and do exercise every day

4 0
3 years ago
Read 2 more answers
What are the inputs of the light dependent reactions?.
bixtya [17]

Answer:

6 water molecules (and technically sunlight/energy)

Explanation:

The inputs of photosynthesis are water and carbon dioxide (and energy); water is used in the light-dependent reactions, and carbon dioxide is used in the light-independent.  The water has to be there to replace the lost electrons in the chlorophyll that leave the thylakoids after being excited by the solar energy.

5 0
2 years ago
What two substances are created in an acid-base neutralization process?
Naily [24]
Um I thought it was salt and water? I might be wrong though..
5 0
3 years ago
___ 1. When the combined effect of two drugs, each producing the same biological response by the same mechanism of action, is eq
Valentin [98]

Answer:

Additive effects

Explanation:

In pharmacology, sometimes more than one drug is used to treat a disorder. The two or more drugs are used as they treat the disease more effectively than they treat the disorder independently.  The two drugs interact in one of the two ways: the additive effect and the synergistic effect.

In the given question, the drugs when combined produce the sum of the drugs equal to the effect shown by the drugs individually therefore the effect of the drug is added. This type of drug interaction is known as the additive effect.

Thus, Additive effect is the correct answer.

4 0
3 years ago
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