I think the first option is the answer.
Answer: Family, Social and Neglect
Explanation:
Family Risk Factors: Family risk factors include childhood maltreatment in which the parent child relationship, marital status of parents, level of understanding among the family members also influences the abuse of alcohol and drug abuse.
Social Risk Factors: The society in which the person or child is living also influences the drug, tobacco and alcohol abuse. A teenage easily gets influenced by the society and place where they are living.
Neglect: If a person feels neglected emotionally by the partners or parents then there is an increased chance of alcohol or drug abuse. If the important necessities of life such as education, clothes, food is fulfilled by the guardians then also there are chances that a person might get towards alcohol and drug abuse.
Polypeptide chains undergo some modifications before they become fully functional. Some of these modifications include: proteolytic cleavage, lipidation and glycosylation. Proteolytic cleavage refers to the removal of some amino acids from a polypeptide chain by proteases in order for the protein to become active. An example of a substance that is modified through this process is insulin.