Question

The extracellular matrix (ECM) of bone is considered to be a composite material made up of organic and inorganic matter. What makes up the organic and inorganic portions of the matrix? Describe the cellular mechanism involved in breaking down this matrix; include the bone cell required for the process.

Answer 1

Answer:

Inorganic portion of matrix:

The inorganic component of extracellular matrix consists of inorganic salts namely calcium and potassium. This salts are present in the crystal of hydroxyapatite. This component provide rigidity and makes the bone as the strongest component of the body.

Organic portion of matrix:

The organic portion of the bone is known as osteoids. They consists of glycosaminolycans, glycoproteins and proteoglycans. The collagen fibers of bones resist torsion of the bones.

The cellular mechanism of the breakdown of the matrix is known as osteoregenreation. The bone cell involved in this process is known as osteoclast that are involved in the process of bone resorption. The bone organic and inorganic component are broken down and reconstruct the extracellular bone matrix.