The answer is Daimyo, the largest magnates in Japan during that time.
Poor workers were often housed in cramped, grossly inadequate quarters. Working conditions were difficult and exposed employees to many risks and dangers, including cramped work areas with poor ventilation, trauma from machinery, toxic exposures to heavy metals, dust, and solvents.
A:water pollution in the river Thames
FYI: This occurred in London, in July and August
The most important holdings were Angola and Mozambique