The transmembrane protein Tango1 is a packaging protein that helps some secretory proteins leave the endoplasmic reticulum (ER)
after synthesis. Knocking down Tango1 by RNA interference impairs the incorporation of collagen VII, but not collagen I, into transport vesicles destined for the Golgi apparatus. The protein contains a lumenal N-terminal SH3 domain and a cytosolic C-terminal proline-rich domain. Which of the following proteins would you expect to interact with the N-terminal and C-terminal domains of Tango1, respectively? A. Procollagen VII; COPI components
B. Procollagen VII; COPII components
C. Procollagen I; COPI components
D. Procollagen I; COPII components
E. COPI components; procollagen I
The endomembrane system present in eukaryotes divides the cell organelle into the structural and functional compartment. This helps in the transport of protein, its signalling and processing of protein.
Tango1 is the packaging protein that are destined to the golgi. The interaction of procollagen VII and CopII vesicle with tango is important as these helps in the transport of tango protein to the golgi. The cop II coated vesicle is important for the transport of the protein that are destined to golgi.
