The answer is geological pick.
Prior to therapy, a high PpIX fluorescence was observed in three patients; however, after iPDT, this fluorescence was entirely photobleached. These patients' viable tumor sections had high PpIX concentrations (mean PpIX uptake per tumor: 1.4-3.0 M).
<h3>Briefing:</h3>
However, no or just minimal PpIX uptake (0-0.6 M) could be seen in the remaining two cases. Strong PpIX uptake patients demonstrated therapeutic response and long-term clinical stabilization (no progression at 29, 30, and 36 months); the remaining two patients experienced early treatment failure (death after 3 and 9 months).
<h3>Describe fluorescence:</h3>
Two steps make up the chemical process of fluorescence first, a chemical fluorophore such a protein or carotenoid absorbs shorter-wavelength light (excitation), and then some of the absorbed energy is released as longer-wavelength light (emission).
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Molecules can diffuse across membranes via transport proteins, or they can be aided in active transport by other proteins. Organelles such as the endoplasmic reticulum, Golgi apparatus, mitochondria and peroxisomes all play a role in membrane transport.
