The discussion of natalizumab treatment 28 days after infection led to stabilization of neuronal injury, reduced numbers of monocytes/macrophages, and reduced productive infection is given in below paragraph-
HIV peripheral neuropathy's pathogenesis depends on the flow of activated monocytes into the dorsal root ganglia (DRG). In SIV-infected macaques, we have demonstrated that increase of freshly recruited (bromodeoxyuridine+ MAC387+) monocytes is linked to severe DRG pathology and loss of intraepidermal nerve fibers. Here, we used natalizumab, which binds to 4-integrins, to treat mice to prevent leukocyte flow. When natalizumab was administered either early (the day of infection) or late (28 days after infection), SIV-infected CD8-depleted macaques were compared to untreated SIV-infected animals slain at comparable dates.
Histopathology revealed diminished DRG pathology with natalizumab therapy, including diminished neuronophagia, inflammation, and Nageotte nodules. When given natalizumab, DRG tissues had less bromodeoxyuridine+ (early), MAC387+ (late), CD68+ (early and late), and SIVp28+ (late) macrophages. Natalizumab treatment had no impact on the quantity of CD3+ T cells in DRGs. All mice given natalizumab experienced decreased levels of the adhesion molecule vascular cell adhesion molecule 1, which regulates leukocyte flow. These results indicate a role for monocyte traffic and activation in HIV peripheral neuropathy by demonstrating that restricting monocyte traffic to the DRG, but not T lymphocyte traffic, reduces inflammation and disease.
<h3>What are macrophages?</h3>
Macrophages are a specific type of white blood cell that surround and eliminate pathogens, clear away dead cells, and activate other immune system cells.
To learn more about macrophages with the help of given link:
brainly.com/question/815350
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