Answer:
Nucleic acids as the hereditary material
Explanation:
The nucleic acids are deoxyribonucleic acids DNA and ribonucleic acids RNA. DNA is an hereditary material that carry information and it is found both in eukaryotic cells and prokaryotic cells. It is found in the nucleus of eukaryotic cells but it is not enclosed in prokaryotic cells.
Numerous degenerative neurological conditions, most notably Parkinson's disease, have been linked to an excessive buildup of alpha synuclein (a-syn) in the brain. Intraneuronal inclusions, often known as Lewy bodies, are neuropathological characteristics seen in Parkinson's disease, Lewy body dementia, and other synucleopathies. The aggregation of a-syn is their main structural component. A-syn accumulation, aggregation, and ensuing Lewy body formation can be attributed to a variety of biological processes. These include genetic changes in parkin, synuclein, or the deubiquitinating enzyme ubiquitin C-terminal hydrolase (UCH-L1), which results in less efficient removal of a-syn via the ubiquitin proteasomal pathway (UPP). Additionally, environmental variables and an age-related decline in antioxidant defense mechanisms that heighten oxidative stress and can have an impact on the formation or clearance of a-syn are intracellular insults.
We focused on changes in the aggregation and clearance of a-syn as impacted by the UPP and the oxidative stress pathways in our dynamic models of a-syn processing in both normal and various disease states. A free radical profile similar to that observed in vivo after exposure to the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine is produced during simulation of enhanced oxidative stress (MPTP). To replicate the kinetics of a-syn that correlates to the neuropathology reported for the sporadic and hereditary types of Parkinson's disease, different model parameters of oxidative stress, UPP failure, or both routes are used. With the use of this in silico model, it is possible to evaluate the kinetics of pathway elements and more accurately identify and validate key pharmaceutical targets.
Learn more about Parkinson's disease brainly.com/question/28169444
#SPJ4
Answer:
look the explanation
Explanation:
The development of antibiotics has revolutionized the treatment of infectious diseases. However, antibiotic overuse is a major contributor to the development of antibiotic-resistant bacteria. Antibiotic resistance is a genetic trait.
Limiting factors are what controls the population of an ecosystem. It also limits the kind of organisms that inhabit it. Limiting factors can be abiotic or biotic. Abiotic factors are the nonliving factors that affect the living ones. From the given options above, the only biotic limiting factor is vegetation. The correct answer would be option B.
Answer:
C. high construction costs
Explanation:
