The gene which is produced once or twice in a lifetime is the milk producing hormone after childbirth. This is because it is produced only after the birth of the child. The growth of the mammary glands takes place during pregnancy. The breast continue to increase in size after giving birth to a child. After delivery only copious milk is produced which is generally done with the help of milk hormone. During pregnancy the secretion of the milk is inhibited by the estrogen and progesterone which circulates in the blood stream which in turn inhibits the release of prolactin from the pituitary gland thus making the mammary glands unresponsive. Where as insulin is a hormone which helps the body to utilise the sugar or glucose from different sources like carbohydrates that we get while we eat food and adrenaline is secreted when we are scared or when we feel that we are in danger. Therefore, milk producing hormone is the gene that are turned once or twice in a lifetime.
Answer:
Exosomes as Therapeutic Target
Given the fact that elevated exosome levels are often correlated with greater severity of different types of cancer, reducing circulating exosomes to normal levels is one of therapeutic strategies to increase treatment efficacy. There are different approaches to modulate exosome production: 1) Inhibition of exosome formation: inhibit crucial proteins involved in exosome formation pathway; 2) Inhibition of exosome release: inhibit important regulators of exosome release process, increased intracellular Ca2+, change cellular microenvironmental pH; 3) Inhibition of exosome uptake: add proteinase for surface proteins on exosomes may serve as receptors for uptake pathways. In addition to control exosomes production, removal of exosomes from the entire circulatory system might be a novel strategy for cancer treatment.
Exosomes could also be used as cancer immunotherapy becasue tumor-derived exosomes carry antigens that is a great source of specific stimulus for the immune response against tumors. Both tumor-derived and dendritic cell-derived exosomes have showed capability to stimulate tumor antigen-specific responses in experimental animal models and human clinical trials.
Exosomes as Targeted Drug Delivery Vehicles
Exosomes became one of the most common methods applied in drug delivery system because of several advantages they have. Firstly, exosomes normally have a small size 40-100 nm, which is more homogenous compared to other microvesicles. This will lead them to evade rapid clearance by the mononuclear phagocyte and enhances passage through fenestrations in the vessel wall. Secondly, due to their endogenous origin, they are less toxic for and better tolerated by the immune system. It facilitates them to avoid causing side effects that normally occur with synthetic nanoparticles. Additionally, the specific ligand or protein expressed on the exosome surface increases efficiency of cargo into the cytosol of the target cell, and therefore fewer off-target effects. Exosomes are generally found most useful as a drug delivery medium in cancer therapy, anti-inflammation and gene interference therapy such as transferring of miRNA.
There are different kinds of cargos encapsulated by exosomes, especially like siRNA or miRNA. The delivery of RNA is attracting because they are rapid degradation in cell circulation and have the limitation in passing through the membrane and in cellular uptake. Chemotherapeutics loaded into exosomes is also used for cancer therapy such as doxorubicin. In principle, there are four key components to achieve correct functionality and efficacy during exosomes drug delivery:1) Choosing the donor cell type to produce drug-carrying exosomes; 2) Using correspond methods to encapsulate the exosomes cargo; 3) Enhancing the specificity of cargo delivery by targeting peptides on the surface of the exosomes; 4) Administrating exosomes to target the area of disease.
Explanation:
https://www.creative-biostructure.com/exosome-applications-652.htm
Answer:
Diffusion
Explanation:
Diffusion is a process of passive transport in which molecules move from an area of higher concentration to one of lower concentration.
Answer: The utilization of different resources requires different adaptations, selecting for different traits.
Explanation:
answers to whole quick check
Birds with larger beaks were better able to utilize the large seeds.
DNA analysis shows that their DNA is almost identical with only minor changes.
The diversity in environments on each island provides many opportunities to study how related organisms have adapted over time.
Scientists observe the frequency of the different forms of the gene and how it changes in response to the environment.
