Question

.A researcher alters the DNA-binding domain of a glucocorticoid receptor to that of an estrogen receptor. How would the cells respond to exposure to glucocorticoids?a. They would bind estrogen, and initiate estrogen-dependent synthesisb. They would bind glucocorticoids, and initiate testosterone-dependent synthesisc. They would bind estrogen, and initiate testosterone-dependent synthesisd. They would bind glucocorticoids, and initiate estrogen-dependent synthesise. They would bind neither hormone

Answer 1

Answer: Transcription

Explanation:

Answer 2

Answer:

d) They would bind glucocorticoids, and initiate estrogen-dependent synthesis

Explanation:

Both Glucocorticoids and estrogens Hormones have important but distinct physiologic functions. These two hormones belongs to the two classes of steroid hormones. Both of these hormones binds to their specific receptors.

DNA binding domain is the domain that after activation by external factors such as hormones express the specific proteins by binding to specific region of the DNA.

As DNA binding domain of a glucocorticoid receptor is altered with DNA binding domain of estrogen receptor so it means binding site of the glucocorticoid hormone for glucocorticoid receptor remains the same and binds to glucocorticoids but on binding it activates the estrogen DNA binding domain which further binds to specific region in the DNA which initiates estrogen dependent synthesis.