Answer:
Explanation:
Pharmacophore (pharmacology) - The molecular framework responsible for a drug's biological activity. According to IUPAC — A pharmacophore is the ensemble of steric and electronic features that is necessary to ensure the optimal supramolecular interactions with a specific biological target structure and to trigger (or to block) its biological response.
Privileged structures are defined as molecular frameworks which are able of providing useful ligands for more than one type of receptor or enzyme target by judicious structural modifications.
1) The 1,4-dihydropyridine ring is present in many biologically important molecules that acts as an important scaffold for cardiovascular drug - a calcium antagonists and although it is technically not considered as a pharmacophore, it is considered as a privileged structure.
1,4-Dihydropyridine (DHP), belongs to the class of calcium antagonist that inhibits the influx of extracellular Ca+2 through the L-type voltage-dependent calcium channels.
A positional substitution in the 4-position is feasible in the heterocyclic ring which in turn culminates in various calcium channel antagonist activities and this heterocyclic ring is the common feature for various pharmacological activities such as anti-inflammatory activity, analgesic activity,
antihypertensive, antianginal, antitumor, antitubercular activity and antithrombotic .
Position on the heterocyclic ring binds to the L-type channel and also to N-type channel on membranes.
2.) The bioisosteres are not a suitable bioisostere for the traditional C-4 aryl or heteroaryl substitution which is necessary for calcium ion blockage thereby inhibiting it to function with the mechanism shared above.
I am confused as to what your question is specifically asking but the chemical formula for aerobic respiration is:
Oxygen + Glucose --------> Carbon Dioxide + Water
O₂ + C₆H₁₂O₆ --------> CO₂ + H₂O
Hopefully this will aid you in answering your question :)
Answer:
The pain nerves in her hand go to the brain to notify it. The brain processes this information and decides to tell the hand to remove itself from the stove. Then, the brain sends this signal back to the hand to make it remove tself from the stove.
Explanation:
Answer:
5.6L
Explanation:
Given parameters:
number of moles = 0.25mol
pressure on gas = 1atm
temperature = 273K
Gas constant R = 0.0821Latm/molK
Unknown:
Volume of gas = ?
Solution:
Using the ideal gas equation, we can solve this problem. The equation is a combination of the three gas laws: Boyle's law, Charles's law and Avogadro's law.
It is mathematically expressed as;
PV = nRT
where P is the pressure
V is the volume
R is the gas constant
T is the temperature
n is the number of moles
All the parameters are in the appropriate units and we simply solve for the volume of the gas;
1 x V = 0.25 x 0.0821 x 273
V = 5.6L
