The slope would be -1. That means that the slope between the two points would be right 2 (numerator) and down 2(denominator). That can be simplified to -1 as the slope.
For this question, you have to take Least Common Multiplier for which in this case will be "45" as, the denominators can get similar and get multiplied by a same value to form a similar expression. This allows us to cancel out them by common factors. Full process shown below.