Answer:
Constitutive activation is the alteration of a protein or signaling pathway such that it is functional or engaged even in the absence of an upstream activating event. For example, RasD is constitutively active because it cannot bind GAP and therefore remains in the GTP-bound, active state even when cells are not stimulated by growth factor to activate a receptor tyrosine kinase.
Constitutively active Ras is cancer promoting because cells will proliferate in the absence of growth factors, and thus normal regulatory mechanisms for cell proliferation are bypassed.
(a) A mutation that resulted in Smad3 binding Smad4, entering the nucleus, and activating transcription independent of phosphorylation by the TGFβ receptor would render Smad3 constitutively active.
(b) A mutation that made MAPK active as a kinase and able to enter the nucleus without being phosphorylated by MEK would render MAPK constitutively active.
(c) A mutation that prevented NF-KB from binding to IK-B or that allowed NF-KB to enter the nucleus and regulate transcription even when bound to IK-B would render NF-KB constitutively active.
Answer:
Antibodies
Explanation:
Specific immune responses are triggered by 'antigens'. Antigens are found on the surface of a pathogen and is used to identify a specific pathogen. Antigens trigger the immune system to release cells that attach themselves to Antigens in order to kill off pathogens. These cells attack Pathogens using <em>antibodies</em>
Answer:
Progesterone, hormone secreted by the female reproductive system that functions mainly to regulate the condition of the inner lining (endometrium) of the uterus. Progesterone is produced by the ovaries, placenta, and adrenal glands
Explanation:
Answer:
1. b. The reaction rate will remain steady over the entire 8 minutes.
2. c. The reaction rate approach zero before 8 minutes.
3. a. The reaction rate will be close to zero over the entire 8 minutes.
4. b. The reaction rate will remain steady over the entire 8 minutes.
Explanation:
When 0.5 mL of enzyme is introduced with water, the reaction will remain steady. When more substrate solution is mixed with water, then reaction will approach to zero depending on the amount of substrate mixed with water.
answer:
By permeating the cell walls and membranes, organic solvents such as alcohols, ether or chloroform can disrupt cells. These solvents are also used to lyse plant cells, in conjunction with shearing forces,
