The major purpose of gene therapy is to deliver genetic materials such as DNA, RNA, and antisense sequences to living cells with the purpose of correcting genetic disorders. Although gene therapy holds great promise as a treatment for disease, the limitation lies in the development of safe and efficient gene-delivery systems. Liposomes serve as one of the effective gene delivery tools owing to its remarkable characteristics in DNA delivery: (i) low immunogenic response; (ii) large amounts of DNA can be loaded easily; (iii) they increase the stability of DNA in the body; and (iv) lack of clearance that improves the DNA blood circulation. There are a variety of diseases which could benefit from liposomal gene therapy, such as cystic fibrosis, sickle cell anemia, immune system deficiencies, and transmissible viral diseases (HIV, hepatitis), neurological diseases (Parkinson’s disease and Alzheimer’s disease), and hemophilia.
