There are so many examples for that in different areas, like TPT1 experiment carried out in our lab recently.Here's one link: http://www.alfa-chemistry.com/tpt1-cas-167218-46-4-item-290583.htm
Human monoclonal antibody (mAbs) are emerging in the field of cancer therapy and have become an increasing proportion of new drugs that are recently approved. Although there are some methods to obtain antigen-specific mAbs from human B cells, it is generally impossible to directly immunize human beings with antigens of interest. For example, for infectious agents, those approaches are largely restricted. To solve these obstacles, two main approaches have been developed; either by humanizing antigen-specific antibodies from small experimental animals (which is laborious due to the great genetic differences from humans) or rely on the in vitro selection of antigen-specific binders from human antibody repertoires. However, the human mAbs developed by these methods are usually with low affinity.
We are now coming up with a much better idea that is humanizing non-human primates mAbs instead of murine mAbs. Due to the close genetic relationship with humans, immunized NHPs have more potential to be isolated with high affinity antibody to human target than other experimental species, such as mouse, rat and rabbit. In addition, with appropriate method, NHP antibodies are much<span> easier to be humanized</span> without any loss of affinity compared to widely used murine antibodies.
Resource: http://www.creative-biolabs.com/High-Affi-TM-Human-Antibody-Discovery.html
<h2>cAMP and glucose mobilization</h2>
Explanation:
It would maintain high cAMP level and elevate glucose mobilization
- Phosphodiesterase is an effector enzyme which degrades secondary messenger cAMP(cyclic adenosine monophosphate)
- Here in this case an inhibitor is inhibiting the phosphodiesterase therefore cAMP level will increase
- As cAMP level rise it activates a protein called protein kinase A which phosphorylates phosphorylase kinase and activates it
- Phosphorylase kinase becomes active that phosphorylates glycogen phosphorylase and makes it active,glycogen phosphorylase catalyse breakdown of glycogen(in liver and muscle cells)
- In liver cells breakdown of glycogen occurs and glucose 1 phosphate gets converted into glucose and supplied to whole body through blood
Answer:182.25 joules
Explanation:
Mass=0.18kg
Velocity=45m/s
Kinetic energy=(mass x(velocity)^2)➗2
Kinetic energy=(0.18 x 45^2) ➗ 2
Kinetic energy=(0.18x45x45) ➗ 2
Kinetic energy=364.5 ➗ 2
Kinetic energy=182.25
Kinetic energy=182.25 joules
Answer:
C. 65 million years ago
Explanation:
The current locations of the continents and their modern day inhabitants, including humans, can be traced to this period.
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