Answer: <span>DNA replication wouldstill occur, but replication of the lagging strand would take much longer than normal.
</span><span><span>DNA ligase is the enzyme that binds the Okazaki fragments in the lagging strand. </span>Since the mutation resulted in much less DNA ligase, there would be less of this enzymes working for the replication process. Doesn't mean it can't happen, but it will be slower.
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Answer:
humans try to modify environment factors to suit their needs. Limiting factors can be controlled in a specific area however, we can't control larger area. Like water or energy.