Answer:
1. The difference between the normal hemoglobin protein DNA sequence and the sickle cell hemoglobin DNA sequence is a base to base shift, in this case adenine (GAG) to thymine (GTG).
2. The difference affects the amino acid sequence of the protein by replacing glutamic acid (Glu) with valine (Val).
Explanation:
In sickle cell anemia, a change in the DNA nucleotide sequence is observed, where adenine is substituted by thymine, whose expression is the change in the amino acid sequence of globine β, incorporating valine instead of glutamic acid. This represents a molecular mutation - point mutation - by subtitution, which corresponds to missense mutation.
<u>Normal hemoglobin protein in a RBC</u>
DNA CTG ACT CCT GAG GAG AAG TCT
Amino acids Leu Thr Pro Glu Glu Lys Ser
<u>Sickle cell hemoglobin protein in a RBC</u>
DNA CTG ACT CCT <em>GTG</em> GAG AAG TCT
Amino acids Leu Thr Pro <em>Val</em> Glu Lys Ser
When GAG is transcribed to mRNA, the CUC codon is obtained, which codes for glutamic acid. Thymine substitution causes the DNA sequence to change to GTG, which is transcribed as CAC, the codon that encodes the amino acid valine. The <u>change from glutamic acid to valine in β-globin causes an altered hemoglobin, giving the abnormal erythrocytes observed in sickle cell disease</u>.
Answer:
D. Sulfur
Explanation:
Electrons are filled in shells. Oxygen has a total of 8 electrons while sulfur has a total of 16 electrons. Out of the total eight electrons, the first shell has two electrons while six electrons are filled in the “s and p” orbits of the second shell giving the outer shell a configuration of "2s2, 2p4".
Likewise, out of the total 16 electrons of sulfur, the last 6 electrons are filled in "s" and "p" orbits of the third shell. Sulfur has a total of six electrons in its outer most shell "3s² 3p⁴". Since the electrons present in the outer most shell are available for chemical reactions and determine the chemical nature of the atom, oxygen and sulfur should exhibit the same chemical properties.
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Answer:
minutes
Explanation:
For a First order reaction, the rate constant is determined by
Where
k= rate constant
t= time required for a reaction
a= initial concentration
x= amount of reactant decomposed in time t
a-x= amount of reactant left after time t
Let the initial concentration be 
Then
Substituting the given values in above equation, we get -
Also,
minutes
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