Denaturation refers to the loss of protein three-dimensional structure when temperature or pH is altered.
Denaturation is the phenomenon in which the tertiary structure of the protein is broken down due to the breakage of bonds between the amino acids of proteins. This breaking of bonds occurs due to the change in pH or temperature from the normal at which the protein remained active.
Three-dimensional structure of the protein is its form in which the protein remains active and functional. It is generally tertiary structure of protein. This active tertiary structure is decided by the sequence of amino acids in the primary structure of protein, where the protein exists as a linear chain.
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