Most of the metabolic activity of the cells occur in cytoplasm.
The cytoplasm is the fluid present in the empty spaces of the cell. All the organelle are found floating in the cytoplasm. Most of the cellular activity and formation takes place here. The nucleus is mainly responsible for the storage of genetic material and synthesis of mRNA. The cell wall is responsible for transportation. In nucleus as well as cell wall do not have space, where the metabolic reactions takes place. Hence, most of the reaction takes place in cytoplasm.
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In the multicellular organism organ system is the most complex level of organisation.
Organ system sometimes referred to as system only is a group of organs, which perform different processes. The organs are made up of tissues. The tissues are a group of cells, which perform a specific function.
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Hence, the correct answer is cytoplasm and systems.