Answer:
Answer explained
Explanation:
a. Overexpression of Axl receptor tyroxine kinase correlates with the decresed patient's overall survival and hence it's inhibition is under process.
AXL TKI BMS777607 treatment increased AXL protein levels after 24 h as observed by Western blot and flow cytometry analysis. Mechanistically, this inhibition-induced AXL cell surface accumulation was neither associated with epigenetic modifications, nor altered transcriptional and translational regulation. Hence this later increased the glycosylated protien abundance in kinase dead mutant. The kinase function blockaging resulted in impaired internalisation which finally incresed the level of proliferation.
An alternative technique may exist in linkage of Axl Tkl to a degradation machinery recruitment unit .
b. Mendelian disorders like cystic fibrosis results from error in the given DNA sequence which can be autosomal dominant and recessive both and also X or Y linked. Mutated gene results in the Mendelian disorders. Whereas in cancer there can be mutation or proliferation of the given cells in a specific area. In cancer cells there is 2.5 times more the mRNA present while 6.2times the DNA and hence the detection and diagnosis automatically becomes difficult as in Mendelian disorders only single sequence needs to be studied at a time .
The answer is D
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The correct answer is option A
Water is the most important component of all living beings. The dependence of organisms on oxygen is much because it an important component of water which is required for the survival. The various types of life processes and metabolic reactions depends on the water to take place. The body is dependent on water for it.
Explanation:
The action of delaying or postponing something is called procrastination.
4-5 ways that you combat procrastination are listed below :
- Getting rid of distractions
- Reward yourself
- Schedule a time for doing task
- Don't be fearful for doing badly at task
- Commit to the task
