Effectiveness and safety?
I believe you are referring to the Water Cycle.
Answer:
1 - "I’ll start to have symptoms when I drink less fluid."
Explanation:
One of the main problems of sickle cell anemia is the crystallization of hemoglobins S, because of the difficulty in binding oxygen to the hemoglobin. This causes obstructions in the blood vessels by the formation of thrombi.
Thus, a higher fluid intake keeps the blood more fluid and prevents vessel obstruction.
Sickle cell anemia is not directly linked to iron deficiency (like common anemia), to white blood cells (in fact, it is directly linked to red blood cells) nor to platelet drop.
Situation
1st link in the accident chain; can be changed to break the chain (ex. Someone is running late for work so he rushes outside to the car.)
Unsafe Habit
2nd link in the accident chain; can be changed to break the chain (ex. He didn't keep an ice scraper in the car and didn't warm up the car ahead of time.)
Unsafe Action
3rd link in the accident chain; can be changed to break the chain (ex. He drove off in his car with frost still covering the windshield.)
Accident
4th link in the accident chain; can be prevented by changing any of the first 3 links (ex. He hits another car because he didn't see it coming.)
Result
5th link in the accident chain; can be prevented by changing any of the first 3 links (ex. He fractures & dislocates his shoulder.)