Prions are misfolded versions of normal proteins that can cause diseases. So the correct option is D.
<h3>What leads to prion disease? </h3>
A misfolded confirmation of proteins is called Prions. These misfolded proteins can result in harmful functional proteins and cause several diseases.
A prion is the type of protein that usually cause the normal proteins in the brain to fold in an abnormal manner. This results in misfolding of proteins in the brain.
Prion diseases are known to affect both humans and animals. Sometimes, humans get prion diseases by consumption of by meat from infected animals.
Creutzfeldt-Jakob disease is the most common prion disease in humans. The occurrence of prion diseases is rare. In the US, about 300 cases are reported every year.
Therefore the correct option is D.
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Answer:
d. The normal bonding between the R groups has been disturbed and the protein loses its normal shape.
Explanation:
Denaturation is the loss of function of a protein due to its altered three-dimensional structure. To function properly, proteins must be present in a properly folded form. The three-dimensional structure and protein folding are mediated by weak interactions such as hydrogen bonds, electrostatic interactions, etc. An abrupt increase in temperature, pH or presence of some organic solvents causes protein denaturation.
The organic solvents target the hydrophobic interactions between the R groups of amino acids that make the core of globular protein stable. Extreme levels of pH target the net charge on proteins and thereby results in electrostatic repulsion between closely placed amino acids. Extremes of pH also disrupt the hydrogen bonding between the R groups of the amino acids. The effect is the loss of the three-dimensional structure of proteins, their partial or complete unfolding and loss of function.
The variety of species of mice around the world demonstrates the creatures' remarkable ability to adapt to different climates, altitudes and food sources.
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