In aplastic anemia, then lab result will be decreased in all blood component( white blood cells, red blood cells, and thrombocyte).
Aplastic anemia is caused by the bone marrow failure. Bone marrow is the place that produces blood cells, so the decrease wouldn't be in the red blood cell only, but in other blood cells too. There shouldn't be any iron deficiency or decreases in the mean corpuscular volume
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Answer:
c. in renal dysfunction, dosage reduction is necessary to avoid seizures
Explanation:
Imipenem is an antibiotic which is given in combination with cilastatin. It is used to treat pneumonia, joint infections, urinary tract infections, sepsis etc. It kills bacteria by interfering with its cell wall formation process. It is metabolized in kidney reducing its half life so cilastatin is given with it to halt its renal metabolism.
Imipenem belongs to carbapenem family of antibiotics. Carbapenem antibiotics can cause seizures specially in people with nervous system disorders or renal failure. Dose must be reduced in patients with renal (kidney) dysfunction otherwise patient's kidneys will be damaged more and since they are already in weak state, it can prove dangerous to the patient.
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