Regarding respiratory changes at birth, changes in blood flow that occur lead to the closure of the foramen ovale the embryonic interatrial connection.
Patent foramen ovale (PFO) is a hole between the left and right atria (upper chambers) of the heart. This hole exists in everyone before birth, but most often closes shortly after being born. PFO is what the hole is called when it fails to close naturally after a baby is born.
The foramen ovale is an aperture in the muscular tissue between the left and right atrium that allows blood to cross the atria and bypass pulmonary circulation during fetal development.
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