A 55-year-old male alcoholic presents with symptoms of liver disease and is found to have mildly elevated liver enzymes. A liver
biopsy examined with a routine hematoxylin and eosin (H&E) stain reveals abnormal clear spaces in the cytoplasm of most of the hepatocytes. Which of the following materials is most likely forming these cytoplasmic spaces? A. Calcium
B. Cholesterol
C. Hemosiderin
D. Lipofuscin
E. Triglyceride
Abnormality in the normal metabolic process may lead to the accumulation of the triglycerides in the hepatocytes of the liver. These can be seen as the clear spaces in the cytoplasm of the liver cells. This can be diagnosed with the routine H and E stain test.
The calcium shows dark blue to purple color, hemosiderin shows yellow brown color, lipofuscin shows golden brown color.
