Answer:
1. P120 is degraded in the 26S proteasome
2. The 26S proteasome has a major role in protein degradation and is critical for protein homeostasis
3. Cell cycle and DNA replication are cellular processes regulated by the Ras and NFkB pathways
Explanation:
The proliferation-associated nucleolar protein (p120) is a protein known to be expressed during the interphase of the cell cycle, specifically in G1 and early S phase, where any problem with DNA replication trigger a checkpoint, i.e., a molecular cascade of signaling events that suspend DNA replication until the problem is resolved. In mammalian cells, the 26S proteasome is responsible for catalyzing protein degradation of about 80% (or even more) of their proteins. The 26S proteasome acts to degrade rapidly misfolded and regulatory proteins involved in the cell cycle, thereby having a major role in protein homeostasis and in the control of cellular processes. It is for that reason that inhibitors that block 26S proteasome function have shown to be useful as therapeutic agents in diseases associated with the failure of protein degradation mechanisms (e.g., multiple myeloma). The NF-κB are highly conserved transcription factors capable of regulating different cellular processes including, among others, cellular growth, inflammatory responses and apoptosis. Moreover, the MAPK/ERK pathway is able to transduce different signals received on the cell surface to the nucleus. The MAPK/ERK pathway is activated when a singling molecule binds to a cell receptor which triggers a signaling cascade that ends when a transcription factor induces the expression of target genes, ultimately producing a response in the cell (for example, the progression through the cell cycle).
When exercise does not increase bone mass, it has been observed that the risk of bone fractures increases due to osteoporosis.
<h3>What are the benefits of exercise to bone mass and density?</h3>
Bone mass refers to the mass of the bones in a living organism as a result of the deposition of minerals within the bone.
An increase in bone mass is directly related to the strength of the bone.
Strong bones have high bone masses whereas weak bone have low bone mass.
Physical activity have been shown to improve bone mass by increase the mass of deposited minerals in the bone.
Exercise such as walking, running, jogging, and other forms of exercise have been shown to improve bone mass and hence, the strength of bones.
However, when exercise does not increase bone mass, osteoporosis is observed which results in bone fracture.
In conclusion, the strength of a bone is directly related to the bone mass which is directly related to the mass of minerals deposited within them.
Learn more about bone mass at: brainly.com/question/10561482
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The correct answer to this question is B. Muscles are building up lactate from anaerobic respiration
Hes trying to infer the density of oak trees (:
