Silk Road:
The Silk Road specifically refers to the trading land routes that connects East and Southeast Asia to South Asia and Persia followed by Arabian Peninsula, East Africa and finally Southern Europe.
This network was regularly used from 130 BCE and part of that road is still in existence as a paved highway that connects Pakistan and the Uygur.
Chinese are the one who first started trading in this road and as its name indicates it is mainly used as a trade route for trading silks.
Hence this ancient road played a major role on times when it was constructed.
Opium wars is the name given to the 19th century conflict between Britain and China, which centered around a dispute between a specific and illegal good being imported into China by English merchants.
Before the 4th century BC, Macedonia was a small kingdom outside of the area dominated by the great city-states of Athens, Sparta and Thebes