It would be C because the ozone layer blocks out harmful radiation from reaching the surface of earth. Hope this helps! - cat
Mosunetuzumab is a T-cell reliant bispecific antibody that binds to CD3 and CD20 to trigger T-cell mediated B-cell death.
However, cytokine release syndrome, which has the potential to limit dose and efficacy, can result from powerful immune stimulation with T-cell focused treatments.
We created a novel mechanistic model of immune and antitumor responses to the T-cell bispecifics (mosunetuzumab and blinatumomab), taking into account the dynamics of B- and T-lymphocytes in circulation, lymphoid tissues, and tumors, in order to better understand the mechanisms underlying safety and efficacy as well as to explore safety mitigation strategies.
Using mosunetuzumab nonclinical and blinatumomab clinical data, the model was created and validated. The initial step-fractionated dose was projected to minimize systemic T-cell activation and cytokine release without impairing tumour response.
Simulations described the mechanisms underlying the observed cell and cytokine (IL6) dynamics. The Phase I clinical study for mosunetuzumab was changed to a step-fractionated treatment schedule as a result of these findings, allowing for the safer administration of greater dosages.
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Answer AND Explanation:
The variations that Darwin regarded as raw materials for the process of evolution have been traced to changes that occur at the gene level or the chromosome and these changes are called mutations. Organisms with beneficial mutations are able to pass them on to their offspring during reproduction. Transmission of such mutations through many generations could lead to the emergence of new species. The emergence of new species requires a long time and is also affected by the rate of mutations that a particular species undergoes. This leads to evolution.
