Please include the multiple choice questions and/or a photo!
Answer:
Okay
Explanation:
Human topoisomerase I plays an important role in removing positive DNA supercoils that accumulate ahead of replication forks. It also is the target for camptothecin-based anticancer drugs that act by increasing levels of topoisomerase I-mediated DNA scission. Evidence suggests that cleavage events most likely to generate permanent genomic damage are those that occur ahead of DNA tracking systems. Therefore, it is important to characterize the ability of topoisomerase I to cleave positively supercoiled DNA. Results confirm that the human enzyme maintains higher levels of cleavage with positively as opposed to negatively supercoiled substrates in the absence or presence of anticancer drugs. Enhanced drug efficacy on positively supercoiled DNA is due primarily to an increase in baseline levels of cleavage. Sites of topoisomerase I-mediated DNA cleavage do not appear to be affected by supercoil geometry. However, rates of ligation are slower with positively supercoiled substrates. Finally, intercalators enhance topoisomerase I-mediated cleavage of negatively supercoiled substrates but not positively supercoiled or linear DNA. We suggest that these compounds act by altering the perceived topological state of the double helix, making underwound DNA appear to be overwound to the enzyme, and propose that these compounds be referred to as ‘topological poisons of topoisomerase I’
lungs can’t remove enough of the carbon dioxide (CO2) that the body produces
Excess CO2 causes the pH of your blood and other bodily fluids to decrease, making them too acidic.
This is called respiratory acidosis
Answer: A surgical puncture of the abdominal cavity to remove excess fluid is known as abdominocentesis
Explanation: Abdominocentesis is a surgical procedure carried out by a train health personnel. It involves puncturing of the peritoneal cavity of the abdomen to access fluid which is drained and used for further diagnosis. Usually the fluid is drained by gravity, a syringe or by connection to a vacuum bottle. The procedure is carried out to:
- relieve abdominal pressure from ascites.
-to diagnose bacterial peritonitis.
-to diagnose blood in peritoneal space in trauma cases.
Answer:
Taking vitamin D by mouth is effective for preventing and treating rickets. A specific form of vitamin D, called calcitriol, should be used in people with kidney failure.
Explanation:
hope it will help you
