Answer:
The CFTR behaves like a channel for chlorine. Its dysfunction affects both the transport of this ion and other ions and the transport of water, which causes a thickening of secretions, an alteration of mucociliary transport and local defenses, facilitating bacterial colonization and promoting the release of pro-inflammatory mediators in the airway
Explanation:
CFTR is a protein expressed in the epithelial cells of the respiratory system, pancreas, bile ducts, sweat glands and genitourinary system. It is made up of a single chain made up of 1,480 amino acids. It contains 12 hydrophobic regions embedded in the lipid membrane and acts as a channel for chlorine.The highest levels of expression of the CFTR protein are found in serous cells of the submucosal glands of the proximal airway. In them, Cl- is released to the outside. In addition, there are channels for Na +, through which this ion is also secreted in the same direction. These movements cause the displacement of water and also of mucins, originating in the submucosal glands, allowing their presence on the surface of the airway. For all this to occur normally, a basolateral Na + - K + - ATPase cotransporter must function, another basolateral cotransporter formed by Na +, K + and 2 Cl-, which allows the latter to enter the cell, and an apical CFTR channel through which it exits the Cl- of the cell towards the acinar lumen. Na + leaves the cell following Cl- by a paracellular pathway accompanied by water. When CFTR malfunctions, Cl- does not exit through this channel and this implies a decrease in Na + and water in the canalicular lumen, with the consequent thickening of secretions.
Answer:
25.5
Explanation:
im big brain sorry if not right :(
Answer: No, the 7:1 ratio is close to the expected 6:2 ratio even with the limited sample size.
Explanation:
Let the alleles be P (purple) and W (white).
The possible crosses are
PP x WW, PP x PW, PW x WW, PW x PW
the F1 is PP or PW
one F2 is white so the F1 must be PW and
the F2 are PP, WW, PW and
the expected 8 progeny are 2PP, 2WW, 4PW
Because 7/8 are purple, we can infer that P is dominant and W recessive, so the expectation is 6 purple, 2 white
The observed ratio is similar to the expected ratio, so we can’t say that this result disproves Mendel, particularly with a small sample.
