<span>Explanation: Oxygen is the more electro-negative of the atoms in the water molecule, so it tends to pull the 'shared' electron more to itself. Thus, the oxygen atom has a greater time-share of all electrons, and therefore the hydrogen atoms are more positive for a partial lack of electrons</span>
At high temperatures the shape of the enzyme is altered so that it is no longer complementary to its specific substrate. This effect can be permanent and irreversible and is called denaturation
