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Jlenok [28]
3 years ago
8

Which of the following intermediary metabolites enters the Krebs cycle and is formed, in part, by the removal of CO2 from a mole

cule of pyruvate?
A) lactate
B) glyceraldehyde phosphate
C) oxaloacetic acid
D) acetyl CoA
E) citric acid
Biology
1 answer:
asambeis [7]3 years ago
6 0

Answer:

The correct answer will be option-D.

Explanation:

Before Citric acid cycle or Krebs cycle, an intermediate reaction takes place which converts the pyruvate into Acetyl CoA. This reaction is known as pyruvate decarboxylation as it produces Carbon dioxide.  

Coenzyme A reacts with pyruvate which causes the release of two oxygen atoms and one carbon to form CO₂ along with the reduction of  NAD+ to NADH and produce "Acetyl CoA."

Thus,  option-D is the correct answer.

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Answer:

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Explanation:

Leptin is produced exclusively in adipose tissue cells in a wide variety of species, including humans, and its concentration is higher in overweight than in lean individuals. The biological actions of leptin can be classified into two groups, those that are exerted in the tissues of the central nervous system, mainly the hypothalamus, and those that are carried out on the peripheral tissues. The former regulate body weight downward, decrease food intake, increase basal energy expenditure and modify some neuroendocrine functions such as reproduction, while the latter have effects on proliferation, differentiation and metabolism of peripheral tissues. The leptin that reaches the hypothalamus, in addition, inhibits protein synthesis and the secretion of neurons producing NPY / AgRP of the arcuate nucleus and stimulates the synthesis and secretion of those containing POMC. NPY (neuropeptide Y) is produced in the hypothalamic arcuate nucleus. This neurotransmitter arrives through the projections of the neurons of said nucleus to the paraventricular nucleus, which is the area where it is released. There are several studies that have shown that an increase in NPY leads to an increase in the sensation of hunger and thus to hyperphagia and obesity. Leptin acts at the level of the arcuate nucleus, preventing the formation of NPY. The leptin receptor lacks enzymatic activity in its intracellular domain. Instead, it is linked to members of the janus kinase family, which belong to a class of tyrosine kinases. The binding of the ligand activates the Jak kinase and leads to the phosphorylation of certain cytoplasmic proteins. Within these proteins there is a class of cytoplasmic transcription factors called signal transducers and activators of transcription (STAT).

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