If a patient with possible STEMI has been having frequent chest discomfort, the contraindication to administering nitrate to the patient is: an history that shows the use of phosphodiesterase inhibitor within the last 24 hours by the patient.

Contraindication refers to the condition that justifies why certain medication cannot be used in a treatment in order to avoid causing more harm to a patient having the condition.

The patient's condition described above calls for careful consideration if nitrate is to be administered as a treatment.

This is because the combination of phosphodiesterase inhibitor with nitrate could lead to a worse serious life-threatening hypotension.

Phosphodiesterase inhibitor and nitrate cannot be used for a patient with STEMI who witnesses ongoing chest discomfort.

Therefore, if a patient with possible STEMI has been having frequent chest discomfort, the contraindication to administering nitrate to the patient is: an history that shows the use of phosphodiesterase inhibitor within the last 24 hours by the patient.

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