The amino acid Prolinehas a pk1 of 1.99, pk2 of 10.60. The amino acid Serine has pk1 of 2.21 and a of pk2 of 9.15. If these two
amino acids bind together by peptide bond creating the peptide sequence Pro-Ser . What will be the overall charge of this peptide at the physiological pH of 7? a) overall charge will be neutral
b) overall charge will be neutral on Pro and negatively charged on the Ser
c) overall charge will be negative
d) overall charge will be positive due to the presence of the peptide bond
The Ph value for Pro will be neutral and neutral charge on the Ser. Molecules of atoms generally have neutral electrical charge. If the overall charge of a peptide is negative then it is considered as negative. Pro and Ser amino acids have neutral Ph values.
