<span>When there is an imbalance
from the homeostasis of the body, a disorder or disease may result. Homeostasis establishes balance and equilibrium of the internal and
external part of the body. If this balance or ideal levels are interrupted, the
body may correct it by making all system work together or the problem may
worsen based on certain influences and may not allow normal functioning of the
organism, by either deficiency or toxicity. </span>
Moreover, some factors that influence
the body’s ability to maintain homeostatic balance are genetics, lifestyle
choices and environmental exposure.
I believe the closest related is speices and class
Answer:
Results
We systematically analyze and compare how different modelling methodologies can be used to describe translation. We define various statistically equivalent codon-based simulation algorithms and analyze the importance of the update rule in determining the steady state, an aspect often neglected. Then a novel probabilistic Boolean network (PBN) model is proposed for modelling translation, which enjoys an exact numerical solution. This solution matches those of numerical simulation from other methods and acts as a complementary tool to analytical approximations and simulations. The advantages and limitations of various codon-based models are compared, and illustrated by examples with real biological complexities such as slow codons, premature termination and feedback regulation. Our studies reveal that while different models gives broadly similiar trends in many cases, important differences also arise and can be clearly seen, in the dependence of the translation rate on different parameters. Furthermore, the update rule affects the steady state solution.
Conclusions
The codon-based models are based on different levels of abstraction. Our analysis suggests that a multiple model approach to understanding translation allows one to ascertain which aspects of the conclusions are robust with respect to the choice of modelling methodology, and when (and why) important differences may arise. This approach also allows for an optimal use of analysis tools, which is especially important when additional complexities or regulatory mechanisms are included. This approach can provide a robust platform for dissecting translation, and results in an improved predictive framework for applications in systems and synthetic biology.
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