The answer that best fits the blank provided above is C3a and C5a. Mast cells release this so called histamines once they are exposed to C3a and C5a which are fragments of complement proteins. These are also called as <span>Anaphylatoxins along with C4a. Hope this helps.</span>
Answer:
1. The difference between the normal hemoglobin protein DNA sequence and the sickle cell hemoglobin DNA sequence is a base to base shift, in this case adenine (GAG) to thymine (GTG).
2. The difference affects the amino acid sequence of the protein by replacing glutamic acid (Glu) with valine (Val).
Explanation:
In sickle cell anemia, a change in the DNA nucleotide sequence is observed, where adenine is substituted by thymine, whose expression is the change in the amino acid sequence of globine β, incorporating valine instead of glutamic acid. This represents a molecular mutation - point mutation - by subtitution, which corresponds to missense mutation.
<u>Normal hemoglobin protein in a RBC</u>
DNA CTG ACT CCT GAG GAG AAG TCT
Amino acids Leu Thr Pro Glu Glu Lys Ser
<u>Sickle cell hemoglobin protein in a RBC</u>
DNA CTG ACT CCT <em>GTG</em> GAG AAG TCT
Amino acids Leu Thr Pro <em>Val</em> Glu Lys Ser
When GAG is transcribed to mRNA, the CUC codon is obtained, which codes for glutamic acid. Thymine substitution causes the DNA sequence to change to GTG, which is transcribed as CAC, the codon that encodes the amino acid valine. The <u>change from glutamic acid to valine in β-globin causes an altered hemoglobin, giving the abnormal erythrocytes observed in sickle cell disease</u>.
I know this answer but it is really commutated
Answer:
In the case of water, hydrogen bonds form between neighboring hydrogen and oxygen atoms of adjacent water molecules. The attraction between individual water molecules creates a bond known as a hydrogen bond. ... Both of these atoms can form a hydrogen bond with oxygen atoms of different water molecules.
Explanation:
Answer: All of the mentioned Scientist made considerable contributions to understanding the DNA molecule in the order:
Explanation: 1.Fredrick Griffith
2. Avery, McCarty and MacLeod
3.Chargaff
4.Hershey and Chase
5.Watson and Crick