Answer: False.
Explanation: The sentence says that "2 in 4 daily calories should come from fat."
2 in 4 is half, so the sentence says that about 50% of the daily calories must come from fat.
Now, according to LiveScience, between 45% to 65% of the daily must come from carbohydrates, between 10% and 35% should come from protein, and between 20% and 25% should come from fats.
Now, whit this in mind, we can say that the sentence is false.