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lbvjy [14]
3 years ago
6

I need someone to help me with my homework in biology.

Biology
1 answer:
Musya8 [376]3 years ago
3 0

Answer:

9= 10. 10=100

Explanation:

thats all i can do

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Two protein kinases, K1 and K2, function sequentially in an intracellular signaling pathway. If either kinase contains a mutatio
Korolek [52]

Answer:

The order must be K2→K1, since the permanently active K1 allele (K1a) is able to propagate the signal onward even when its upstream activator K2 is inactive (K2i). The reverse order would have resulted in a failure to signal (K1a→K2i), since the permanently active K1a kinase would be attempting to activate a dead K2i kinase.

Explanation:

  • You characterize a double mutant cell that contains K2 with type I mutation and K1 with type II mutation.
  • You observe that the response is seen even when no extracellular signal is provided.
  • In the normal pathway, i f K1 activat es K2, we expect t his combinat ion of two m utants to show no  response with or without ext racell ular signal. This is because no matt er how active K1 i s, it would be unable to  act ivate a mutant K2 that i s an activit y defi cient. If we reverse the order, K2 activating K1, the above  observati on is valid. Therefore, in the normal signaling pathway, K2 activates K1.
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3 years ago
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