The answer is leukoplakia. Leukoplakia is a condition in which thick, leathery white spots develop in the mouth. Smoking is the leading cause of leukoplakia, so people addicted to smokeless tobacco at a very high risk of developing the disease. Mild leukoplakia is generally harmless and would typically resolve on its own but more severe cases may be linked to oral cancer.
Well the only one that makes most sense is the flight or fight response because your body senses danger causing ur adrenalin to get shot up which would allow ur body to feel more safe. Hope this helped :)