Question

De novo purine synthesis occurs by the stepwise addition of atoms or groups of atoms to 5‑phosphoribosyl 1‑pyrophosphate (PRPP). The atoms of the purine rings are supplied by glutamate, glycine, glutamine, aspartate, and N 10 ‑formyltetrahydrofolate (THF). Inosine monophosphate (IMP), the product of the pathway, is a purine nucleotide that can be converted to either AMP or GMP. The structure of the base is labeled according to the numbering convention for purines. Identify the direct source of each atom in the purine ring of IMP.

Answer 1

Answer:

Explanation:

Like we all know, the purine ring of IMP is made up of a nine membered compound . they are heterocyclic aromatic organic compound that consist of a pyrimidine ring fused to an imidazole ring. there are four nitrogen atoms and five carbon atom.

The ring is imidazole ring is made up of N1, C2, N3, C4, C5, C6 with the pyrimidine sharing C4 and C5 with the imidazole ring and also made up of N7, C8, N9.

the direct source of N1 is from aspartate

the direct source of C2 and C8 is from N 10 ‑formyltetrahydrofolate (THF)

N3 and N9 is derived from the amide group of Glutamine

C4, C5 and N7 is derivd from Glycine

C6 is derived from bicarbonate