Numerous degenerative neurological conditions, most notably Parkinson's disease, have been linked to an excessive buildup of alpha synuclein (a-syn) in the brain. Intraneuronal inclusions, often known as Lewy bodies, are neuropathological characteristics seen in Parkinson's disease, Lewy body dementia, and other synucleopathies. The aggregation of a-syn is their main structural component. A-syn accumulation, aggregation, and ensuing Lewy body formation can be attributed to a variety of biological processes. These include genetic changes in parkin, synuclein, or the deubiquitinating enzyme ubiquitin C-terminal hydrolase (UCH-L1), which results in less efficient removal of a-syn via the ubiquitin proteasomal pathway (UPP). Additionally, environmental variables and an age-related decline in antioxidant defense mechanisms that heighten oxidative stress and can have an impact on the formation or clearance of a-syn are intracellular insults.
We focused on changes in the aggregation and clearance of a-syn as impacted by the UPP and the oxidative stress pathways in our dynamic models of a-syn processing in both normal and various disease states. A free radical profile similar to that observed in vivo after exposure to the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine is produced during simulation of enhanced oxidative stress (MPTP). To replicate the kinetics of a-syn that correlates to the neuropathology reported for the sporadic and hereditary types of Parkinson's disease, different model parameters of oxidative stress, UPP failure, or both routes are used. With the use of this in silico model, it is possible to evaluate the kinetics of pathway elements and more accurately identify and validate key pharmaceutical targets.
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1. Answer: A
Explanation: For a cell to form proteins, the specific types of proteins are coded for by the genes in DNA (found in the chromosomes of the nucleus). To produce proteins, the genes are first transcribed by RNA polymerase to form messenger-RNA. The mRNA is then translated into proteins by ribosomes in the cytoplasm of the cell.
2. Answer: B
Explanation: Translation of genes into proteins is dependent on the sequence of nucleotides. They are translated in sequences of 3 nucleotides known as codons. Therefore adding a nucleotide on a piece of DNA causes what is referred to as a frame-shift mutation. The 3 sequences (of codons) is interrupted and shifted by one nucleotide. Therefore, the codons change and the amino acids translated will also change.
3. Answer: A
Expanation: Producers are significant in a food chain because they incorporate the energy of the sun into the food chain. This is why they are at the base of the food chain and have the largest biomass. They are consumed by primary consumers which are consumed by secondary consumers which are consumed by tertiary consumers and so on.
4. Answer: D
Explanation: Plants are consumed by herbivores. Therefore, a decrease in plant population due to drought was resulted to decrease in herbivore population. This is due to stiff competition by the herbivores for the scarce plant population. Carnivores consume herbivores. Due to a decrease in the herbivore population, then the carnivore population would also decrease.
5. Answer: A
Explanation: Burning of fossil fuels emits carbon dioxide gas which is a greenhouse gas. Greenhouse gas traps infrared wavelength of lights hence warming up the atmosphere, causing global warming. Reduction in use of fossil fuels will hence alleviate an increase in global temperature hence protect coral in the oceans from bleaching.
Backup of sewage in the preparation area or a serious pest infestation are hazards or contaminants that are grounds for immediate closure of an operation. A sewer drain backup may be among the most unpleasant experiences one can get as a house owner.
The answer is D. The river basin goes out into the ater shed leading straight for the ocean!
