Malonate is a competitive inhibitor of succinate dehydrogenase. If malonate is added to a mitochondrial preparation that is oxid

Question

3 years ago

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Malonate is a competitive inhibitor of succinate dehydrogenase. If malonate is added to a mitochondrial preparation that is oxid

izing pyruvate as a substrate, which of the following compounds would you expect to initially decrease in concentration?A) Citrate
B) Fumarate
C) Isocitrate
D) Pyruvate
E) Succinate

Biology

1 answer:

Monica [59] · Answer 1 · 2022-03-04T15:58:02+03:00

<h2>B) is the correct option </h2>

Explanation:

Succinate dehydrogenase is the smallest component of electron transport chain and consists of four different subunits including FAD, 3 Fe-S centers
It catalyzes oxidation of succinate to fumarate and electrons released transferred to ubiquinone
Succinate dehydogenase transfer electrons from succinate to ubiquinone via FADH2 thus this complex directly links tricarboxylic acid cycle to electron transport chain
Activity of succinate dehydrogenase is inhibited by malonate which is a competitive inhibitor as a result oxidation of succinate to fumarate will not occur and hence concentration of fumarate will decrease