Extensive damage to oligodendrocytes in the cns could result in l<u>oss of sensation and motor control.</u>
Explanation:
Oligodendrocytes are presnt in glial cells of Central nervous System which comprises of Brain and spinal cord.They are related to the nerve cells. It provides support by production of glial cell line derived neutrophic factor (GDNF) and brain derived neurotrophic factor (BDNF) or insulin growth factor IGF-1 they reduce ion leakage and decrease the capacitance of the cell membrane. Due to intensive damage of the Oligodendrocytes the motor nerves and other nerves of CNS damages looses it activity.
These are mainly occurred due to peripheral injury or demylinated diseases like multiple sclerosis, leukodystrophies,cerebral plasy and other congential disorders.Some chemicals like fluorouracil causes damage to the oligodendrocytes.
