Human monoclonal antibody (mAbs) are emerging in the field of cancer therapy and have become an increasing proportion of new drugs that are recently approved. Although there are some methods to obtain antigen-specific mAbs from human B cells, it is generally impossible to directly immunize human beings with antigens of interest. For example, for infectious agents, those approaches are largely restricted. To solve these obstacles, two main approaches have been developed; either by humanizing antigen-specific antibodies from small experimental animals (which is laborious due to the great genetic differences from humans) or rely on the in vitro selection of antigen-specific binders from human antibody repertoires. However, the human mAbs developed by these methods are usually with low affinity.
We are now coming up with a much better idea that is humanizing non-human primates mAbs instead of murine mAbs. Due to the close genetic relationship with humans, immunized NHPs have more potential to be isolated with high affinity antibody to human target than other experimental species, such as mouse, rat and rabbit. In addition, with appropriate method, NHP antibodies are much<span> easier to be humanized</span> without any loss of affinity compared to widely used murine antibodies.
Resource: http://www.creative-biolabs.com/High-Affi-TM-Human-Antibody-Discovery.html
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There are four possible combinations of gametes for the AaBb parent. Half of the gametes get a dominant A and a dominant B allele; the other half of the gametes get a recessive a and a recessive b allele. Both parents produce 25% each of AB, Ab, aB, and ab.
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I think the answer is 2 or 1
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(so sorry if im wrong)
If Lorenzo would quit smoking,reduce his intake of alcohol and improve his healthy eating behaviors and also increasing his physical activity it would mean his lifestyle changes would then increase telomerase activity. Increase telomerase is one way of the body to deal with stress and for the protection of DNA from destruction.
