Karen can deal with theories of self boundaries in this situation by being assertive, only do what makes her comfortable, and communication and etc.
Explanation:
If Karen wants to establish self boundaries she needs to practice certain things in order to set boundaries. Few are as such:
She needs to be assertive with her co-worker, which means when she speaks, the co-worker can easily detect that her decision/statements are not changing.
She needs to prioritize herself before other. Only doing what she is comfortable with.
When the other person shows respect for your boundaries, thank them.
John Locke was the philosopher who maintained that knowledge comes from experience via the senses, and therefore, science should rely on obersvations and experiments.