Question

Ricardo Richardson works in environmental services for a local hospital. He is being evaluated in your clinic for possible HIV exposure after lacerating his hand on a contaminated sharp object from an​ HIV-positive source. Postexposure prophylaxis is prescribed to minimize his risk for acquiring HIV. What pharmacotherapy do you expect the health care provider to​ order?
a) Zidovudine​ (Retrovir) and emtricitabine​ (Emtriva)
b) Maraviroc​ (Selzentry) and raltegravir​ (Isentress)
c) Nevirapine​ (Viramune) and delavirdine​ (Rescriptor)
d) Darunavir​ (Prezista) and nelfinavir​ (Viracept)

Answer 1

Answer: A. Zidovudine​ (Retrovir) and emtricitabine​ (Emtriva)

Explanation:

Basic postexposure prophylaxis​ (PEP) therapy typically includes treatment with one of these combinations of pharmacologic​ agents:

Zidovudine​ (Retrovir) and emtricitabine​ Emtriva),

Lamivudine​ (Epivir) and tenofovir​ (Viread), or

Tenofovir​ (Viread) and emtricitabine​ (Emtriva)

If the accidental exposure is especially​ severe, a third agent may be included.