During which if the following months is the sun likely to illuminate Earth equally from pole to Pole?

1 answer:

6 0

The answer is March and September. This period is referred to as the equinox when the sun is overhead the equator. The days and nights are equal all over the earth. June 21 and December 21, on the other hand, are the date-months when the two solstices (when the earth is at the extreme north and south latitude latitudes) occur on earth.

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The sequence ATAGACC would correspond to the following after transcription

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Your medical bill is 2345 your health insurance covers 70% after a 120 deductible what amount of the bill will you pay

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Based on the definitions of pharmacophore and privileged structure, outline essential structural features a 1,4-dihyrdopyridine

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Explanation:

Pharmacophore (pharmacology) - The molecular framework responsible for a drug's biological activity. According to IUPAC — A pharmacophore is the ensemble of steric and electronic features that is necessary to ensure the optimal supramolecular interactions with a specific biological target structure and to trigger (or to block) its biological response.

Privileged structures are defined as molecular frameworks which are able of providing useful ligands for more than one type of receptor or enzyme target by judicious structural modifications.

1) The 1,4-dihydropyridine ring is present in many biologically important molecules that acts as an important scaffold for cardiovascular drug - a calcium antagonists and although it is technically not considered as a pharmacophore, it is considered as a privileged structure.

1,4-Dihydropyridine (DHP), belongs to the class of calcium antagonist that inhibits the influx of extracellular Ca+2 through the L-type voltage-dependent calcium channels.

A positional substitution in the 4-position is feasible in the heterocyclic ring which in turn culminates in various calcium channel antagonist activities and this heterocyclic ring is the common feature for various pharmacological activities such as anti-inflammatory activity, analgesic activity,

antihypertensive, antianginal, antitumor, antitubercular activity and antithrombotic .

Position on the heterocyclic ring binds to the L-type channel and also to N-type channel on membranes.

2.) The bioisosteres are not a suitable bioisostere for the traditional C-4 aryl or heteroaryl substitution which is necessary for calcium ion blockage thereby inhibiting it to function with the mechanism shared above.

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What are 4 types of chemical weathering?

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Dissolution
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Carbonation
Hydrolysis

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