Question

What two types of amino acid sequences are needed in a protein to mediate post-translational farnesylation?

Answer 1

Answer:

Post translation farnesylation may be defined as a type of prenylation in which the isoprenyl group is added to the cysteine residues of the protein. This modification is important for protein and membrane interaction.

Basically two types of amino acid are required for the farsenylation modification. The signal peptide sequence is the short amino acid sequence that targets the ribosome in the endoplasmic reticulum. The sequence is generally lysine, aspartic acid, glutamic acid and leucine. The second sequence must be Caax (C is cysteine, a is aliphatic amino acid and X consists of C terminal amino acid.